NICE has published final draft guidance recommending a breakthrough cancer treatment, called CAR T-cell therapy, for adults with certain types of non-Hodgkin lymphoma.
Axicabtagene-ciloleucel, also known as Yescarta and manufactured by Kite, a Gilead company, is part of a new wave of personalised medicine.

The therapy is for adults with relapsed or refractory diffuse large B-cell lymphoma or primary mediastinal large B-cell lymphoma, two aggressive subtypes of non-Hodgkin lymphoma. It will be offered to people whose disease has not responded after two or more rounds of chemotherapy or relapsed after a stem cell transplant.

Axicabtagene-ciloleucel is recommended within the Cancer Drugs Fund, giving people access to the treatment while more data is collected.
CAR T-cell therapy for these lymphoma patients will be available at seven hospitals as the service is rolled out across the country.

Meindert Boysen, Director of the Centre for Health Technology Evaluation, NICE, explained, ‘People with these aggressive subtypes of non-Hodgkin lymphoma often have very poor outcomes. NICE’s recommendation is exciting because it means that adults will have access to a CAR T-cell therapy through the Cancer Drugs Fund.

‘It is great to see that NHS England is preparing to deliver CAR T-cell therapy as quickly as possible and we hope that people can start treatment soon.’